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Researchers test new nanopore DNA sequencing technology to detect cause of antibiotic resistance
New nanopore DNA sequencing technology on a device the size of a USB stick could be used to diagnose infection. A research team from the University of East Anglia and Public Health England tested a new device called MinION, produced by Oxford Nanopore Technologies Ltd. The machine produces long sequencing reads, important when trying to determine where resistance genes are.
Researchers proved its utility by successfully mapping the exact spot in genes which makes them drug-resistant, known as an antibiotic resistance island. The MinION took just 18 hours to produce the results, with similar accuracy to current technologies.
Lead researcher Dr Justin O’Grady, from UEA’s Norwich Medical School, said: “This type of technology will revolutionise the way that we characterise the rapid spread of emerging antibiotic-resistant infectious diseases.
Oxford Nanopore Technologies is an Oxford University spinout, based at the University’s Begbroke Science Park from 2005 – 2009.